Long-term fluoxetine treatment modulates cannabinoid type 1 receptor-mediated inhibition of adenylyl cyclase in the rat prefrontal cortex through 5-hydroxytryptamine 1A receptor-dependent mechanisms.

@article{Mato2010LongtermFT,
  title={Long-term fluoxetine treatment modulates cannabinoid type 1 receptor-mediated inhibition of adenylyl cyclase in the rat prefrontal cortex through 5-hydroxytryptamine 1A receptor-dependent mechanisms.},
  author={Susana Mato and Rebeca Vidal and Elena Castro and Alvaro H. Diaz and {\'A}ngel Pazos and Elsa Mar{\'i}a Valdiz{\'a}n},
  journal={Molecular pharmacology},
  year={2010},
  volume={77 3},
  pages={424-34}
}
Increasing data indicate that brain endocannabinoid system plays a role in the effects of antidepressant medications. Here we examined the effect of in vivo exposure to the selective serotonin uptake inhibitor fluoxetine on cannabinoid type 1 (CB(1)) receptor density and functionality in the rat prefrontal cortex (PFC) and cerebellum. Long-term treatment with fluoxetine (10 mg/kg/day) enhanced CB(1) receptor inhibition of adenylyl cyclase (AC) in the PFC and reduced it in the cerebellum without… CONTINUE READING
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A (2008) WAY100635 prevents the changes induced by fluoxetine upon the 5-HT1A receptor

  • E Castro, A Díaz, A Rodriguez-Gaztelumendi, E Del Olmo, Pazos
  • Neuropharmacology
  • 2008
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