Long-term fluoxetine treatment induces input-specific LTP and LTD impairment and structural plasticity in the CA1 hippocampal subfield

@inproceedings{Rubio2013LongtermFT,
  title={Long-term fluoxetine treatment induces input-specific LTP and LTD impairment and structural plasticity in the CA1 hippocampal subfield},
  author={Francisco J. Rubio and Est{\'i}baliz Ampuero and Rodrigo Sandoval and Jorge Ribeiro de Toledo and Floria C Pancetti and Ursula Wyneken},
  booktitle={Front. Cell. Neurosci.},
  year={2013}
}
Antidepressant drugs are usually administered for several weeks for the treatment of major depressive disorder. However, they are also prescribed in several additional psychiatric conditions as well as during long-term maintenance treatments. Antidepressants induce adaptive changes in several forebrain structures which include modifications at glutamatergic synapses. We recently found that repetitive administration of the selective serotonin reuptake inhibitor (SSRI) fluoxetine to naïve adult… CONTINUE READING
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  • Rubio, Ampuero, Sandoval, Toledo, Pancetti, Wyneken
  • 2013

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