Long-term fluoxetine, but not desipramine, inhibits the ACTH and oxytocin responses to the 5-HT1A agonist, 8-OH-DPAT, in male rats

@article{Li1993LongtermFB,
  title={Long-term fluoxetine, but not desipramine, inhibits the ACTH and oxytocin responses to the 5-HT1A agonist, 8-OH-DPAT, in male rats},
  author={Qian Li and Andrew D. Levy and Theresa M. Cabrera and Mark S. Brownfield and Louis D. van de Kar},
  journal={Brain Research},
  year={1993},
  volume={630},
  pages={148-156}
}
  • Qian Li, Andrew D. Levy, +2 authors Louis D. van de Kar
  • Published in Brain Research 1993
  • Medicine, Biology
  • The present studies determined whether serotonin 5-HT1A receptor-mediated function is modified by chronic exposure to antidepressants. Hormone responses to the 5-HT1A agonist, 8-OH-DPAT, were evaluated after long-term exposure to two antidepressants, the 5-HT uptake blocker, fluoxetine, and the norepinephrine uptake blocker, desipramine (DMI). In addition, the density and affinity of 5-HT1A receptors in the hypothalamus and cerebral cortex were measured. Male rats received fluoxetine (10 mg/kg… CONTINUE READING

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