Long-term favorable response to interferon beta-1b is linked to cytokine deviation toward the Th2 and Tc2 sides in Japanese patients with multiple sclerosis.

@article{Mei2006LongtermFR,
  title={Long-term favorable response to interferon beta-1b is linked to cytokine deviation toward the Th2 and Tc2 sides in Japanese patients with multiple sclerosis.},
  author={F R Mei and Manabu Osoegawa and Hirofumi Ochi and Motozumi Minohara and Shi Nan and Hiroyuki Murai and Takaaki Ishizu and Takayuki Taniwaki and Jun-ichi Kira},
  journal={Journal of the neurological sciences},
  year={2006},
  volume={246 1-2},
  pages={71-7}
}
To address the immune mechanism of the long-term beneficial effects of interferon beta (IFN-beta), we measured the intracellular cytokine production patterns of IFN-gamma, IL-4 and IL-13 in peripheral blood CD4+ and CD8+ T cells, which previously displayed alterations during the early course of IFN-beta treatment, in 15 Japanese patients after long-term IFN-beta administration. The patients were treated with IFN-beta-1b 8 x 10(6) units given subcutaneously every other day for a mean period of… CONTINUE READING

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