Long-term expression of Fos-related antigen and transient expression of delta FosB associated with seizures in the rat hippocampus and striatum.

@article{Bing1997LongtermEO,
  title={Long-term expression of Fos-related antigen and transient expression of delta FosB associated with seizures in the rat hippocampus and striatum.},
  author={Guoying Bing and Wei-xi Wang and Qing-sheng Qi and Z Feng and Peter Hudson and L Jin and Wenru Zhang and Robert K. Bing and Jau Shong Hong},
  journal={Journal of neurochemistry},
  year={1997},
  volume={68 1},
  pages={272-9}
}
Systemic administration of kainic acid (KA), an analogue of glutamic acid, causes limbic seizures and pathophysiological changes in adult rats that are very similar to human temporal lobe epilepsy. One of the earliest changes in gene expression after treatment with KA is the induction of immediate-early genes. The fos and jun families are frequently studied immediate-early genes that are induced by KA. Several groups, including ours, have recently reported that a 35-kDa Fos-related antigen (FRA… CONTINUE READING

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