Long-term exposure to ethanol downregulates tight junction proteins through the protein kinase Cα signaling pathway in human cerebral microvascular endothelial cells

  title={Long-term exposure to ethanol downregulates tight junction proteins through the protein kinase C$\alpha$ signaling pathway in human cerebral microvascular endothelial cells},
  author={Hao Yu and Chang-liang Wang and Xiaolong Wang and Hongbo Wang and Chunan Zhang and Jiabin You and Pengfei Wang and Chunmei Feng and Guohui Xu and Rui Zhao and Xu Wu and Guohua Zhang},
  journal={Experimental and Therapeutic Medicine},
  pages={4789 - 4796}
Brain microvascular endothelial cells (BMECs) are the primary component of the blood-brain barrier (BBB). Tight junction (TJ) proteins, including claudin, occludin and zonula occludens (ZO)-1, ZO-2 and ZO-3, maintain the structural integrity of BMECs. Ethanol activates the assembly and disassembly of TJs, which is a process that is regulated by protein kinase C (PKC). In addition, ethanol treatment leads to the loss of structural integrity, which damages the permeability of the BBB and… Expand
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  • C. L. Willis, Diana S. Meske, T. Davis
  • Biology, Medicine
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2010
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