Long-term exposure to combination antiretroviral therapy and risk of death from specific causes: no evidence for any previously unidentified increased risk due to antiretroviral therapy.

@article{Kowalska2012LongtermET,
  title={Long-term exposure to combination antiretroviral therapy and risk of death from specific causes: no evidence for any previously unidentified increased risk due to antiretroviral therapy.},
  author={Justyna D Kowalska and Joanne Reekie and Amanda Mocroft and Peter Reiss and Bruno Ledergerber and Jose M. Gatell and Antonella d'Arminio Monforte and Andrew N Phillips and Jens D. Lundgren and Ole Kirk},
  journal={AIDS},
  year={2012},
  volume={26 3},
  pages={315-23}
}
BACKGROUND Despite the known substantial benefits of combination antiretroviral therapy (cART), cumulative adverse effects could still limit the overall long-term treatment benefit. Therefore we investigated changes in the rate of death with increasing exposure to cART. METHODS A total of 12 069 patients were followed from baseline, which was defined as the time of starting cART or enrolment into EuroSIDA whichever occurred later, until death or 6 months after last follow-up visit. Incidence… CONTINUE READING
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