Long-term exposure to circulating platinum is associated with late effects of treatment in testicular cancer survivors

@inproceedings{Boer2015LongtermET,
  title={Long-term exposure to circulating platinum is associated with late effects of treatment in testicular cancer survivors},
  author={Hink Boer and Johannes H Proost and Janine Nuver and S. Bunskoek and J. Q. Gietema and B. M. Geubels and Renske Altena and Nynke Zwart and Sjoukje F. Oosting and Judith M Vonk and Joop Daniel Lefrandt and Donald R. A. Uges and Coby Meijer and Elisabeth G. E. de Vries and Jourik A. Gietema},
  booktitle={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2015}
}
BACKGROUND The success of cisplatin-based (Platinol, Bristol-Myers Squibb Company, New York, NY, USA) chemotherapy for testicular cancer comes at the price of long-term and late effects related to healthy tissue damage. We assessed and modelled serum platinum (Pt) decay after chemotherapy and determined relationships between long-term circulating Pt levels and known late effects. PATIENTS AND METHODS In 99 testicular cancer survivors, treated with cisplatin-based chemotherapy, serum and 24-h… CONTINUE READING
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