Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6J mice. A potential model of sporadic Alzheimer’s disease

@article{Busquets2017LongtermET,
  title={Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6J mice. A potential model of sporadic Alzheimer’s disease},
  author={Oriol Busquets and Miren Ettcheto and Merc{\`e} Pall{\`a}s and Carlos Beas-Z{\'a}rate and Antoni Camins},
  journal={Mechanisms of Ageing and Development},
  year={2017},
  volume={162},
  pages={38-45}
}
AIMS The sporadic and late-onset form of Alzheimer's disease (AD) constitutes the most common form of dementia. This non-familiar form could be a consequence of metabolic syndrome, characterized by obesity and the development of a brain-specific insulin resistance known as type III diabetes. This work demonstrates the development of a significant AD-like neuropathology due to these metabolic alterations. METHODS C57BL/6J mice strain were divided into two groups, one fed with a diet rich in… CONTINUE READING
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