Long-term experience with a calcium-thiazide treatment for Paget's disease of bone.

@article{Evans1982LongtermEW,
  title={Long-term experience with a calcium-thiazide treatment for Paget's disease of bone.},
  author={Richard A. Evans and Colin Robert Dunstan and Siu Yin Wong and E E Hills},
  journal={Mineral and electrolyte metabolism},
  year={1982},
  volume={8 6},
  pages={325-33}
}
75 patients with Paget's disease of bone were treated with a drug combination intended to increase the production of endogenous calcitonin and decrease that of parathyroid hormone. The first regimen of oral calcium, thiazide diuretic, aluminum hydroxide and low-phosphorus diet was given to 41 patients for a mean of 800 days. A simpler regimen of oral calcium and thiazide diuretic was given to 34 patients for a mean of 750 days. There was a similar fall in mean plasma alkaline phosphatase to 71… CONTINUE READING

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