Long-term exercise-specific neuroprotection in spinal muscular atrophy-like mice.

  title={Long-term exercise-specific neuroprotection in spinal muscular atrophy-like mice.},
  author={Farah Chali and C{\'e}line Desseille and L{\'e}o Houdebine and Evelyne Benoit and Tha{\"i}s Rouquet and Bruno Bariohay and Philippe Lopes and Julien Branchu and Bruno della Gaspera and Claude Pariset and Christophe Chanoine and Fr{\'e}d{\'e}ric Charbonnier and Olivier Biondi},
  journal={The Journal of physiology},
  volume={594 7},
KEY POINTS The real impact of physical exercise parameters, i.e. intensity, type of contraction and solicited energetic metabolism, on neuroprotection in the specific context of neurodegeneration remains poorly explored. In this study behavioural, biochemical and cellular analyses were conducted to compare the effects of two different long-term exercise protocols, high intensity swimming and low intensity running, on motor units of a type 3 spinal muscular atrophy (SMA)-like mouse model. Our… CONTINUE READING
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A mouse model for spinal muscular atrophy

Nature Genetics • 2000
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