Long-term evaluation of the efficacy and safety of loreclezole as add-on therapy in patients with uncontrolled partial seizures: a 1-year open follow-up

@article{Rentmeester1991LongtermEO,
  title={Long-term evaluation of the efficacy and safety of loreclezole as add-on therapy in patients with uncontrolled partial seizures: a 1-year open follow-up},
  author={Th. W Rentmeester and Alice Janssen and Jacques Hulsman and F{\'e}lix Scholtes and Frank de Beukelaar},
  journal={Epilepsy Research},
  year={1991},
  volume={9},
  pages={65-70}
}
The effect and safety of loreclezole were evaluated during a long-term follow-up trial targeting higher plasma concentrations than those of the preceding controlled trial. The result is better than in the double-blind trial, in which loreclezole doses were administered to reach plasma concentrations of 1-2 mg/l and 6/32 patients (19%) of the verum group experienced a seizure reduction of 50% or more. None of the 30 placebo-treated patients experienced a similar decrease. At the end of the… CONTINUE READING
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