Long-term evaluation of combined prolonged-release oxycodone and naloxone in patients with moderate-to-severe chronic pain: pooled analysis of extension phases of two Phase III trials

@inproceedings{Blagden2014LongtermEO,
  title={Long-term evaluation of combined prolonged-release oxycodone and naloxone in patients with moderate-to-severe chronic pain: pooled analysis of extension phases of two Phase III trials},
  author={Mark D Blagden and Julia Hafer and Heike E Duerr and Michael Hopp and Bjoern Bosse},
  booktitle={Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society},
  year={2014}
}
BACKGROUND While opioids provide effective analgesia, opioid-induced constipation (OIC) can severely impact quality of life and treatment compliance. This pooled analysis evaluated the maintenance of efficacy and safety during long-term treatment with combined oxycodone/naloxone prolonged-release tablets (OXN PR) in adults with moderate-to-severe chronic pain. METHODS Patients (N = 474) received open-label OXN PR during 52-week extension phases of two studies, having completed 12-week, double… CONTINUE READING