Long-term ethanol exposure inhibits glucose transporter 4 expression via an AMPK-dependent pathway in adipocytes

@inproceedings{Feng2010LongtermEE,
  title={Long-term ethanol exposure inhibits glucose transporter 4 expression via an AMPK-dependent pathway in adipocytes},
  author={Li Feng and Yong-feng Song and Qing-bo Guan and Hong-jun Liu and Bo Ban and Hai-xin Dong and Xiao-lei Hou and Kok-onn Lee and Ling Gao and Jia-jun Zhao},
  booktitle={Acta Pharmacologica Sinica},
  year={2010}
}
AbstractAim:The roles of AMP-activated protein kinase (AMPK) and myocyte enhancer factor 2 isoforms (MEF2A, D) as mediators of the effects of ethanol on glucose transporter 4 (GLUT4) expression are unclear. We studied the effects of ethanol in adipocytes in vivo and in vitro.Methods:Thirty-six male Wistar rats were divided into three groups and given ethanol in a single daily dose of 0, 0.5, or 5 g/kg for 22 weeks. The expression of AMPK, MEF2 isoforms A and D, and GLUT4 was measured and… CONTINUE READING
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