Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors.

@article{Haidet2008LongtermEO,
  title={Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors.},
  author={Amanda M Haidet and Liza Rizo and Chalonda R. Handy and Priya Umapathi and Amy Eagle and Chris Shilling and Daniel R. Bou{\'e} and Paul T. Martin and Zarife Sahenk and Jerry R. Mendell and Brian K Kaspar},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 11},
  pages={4318-22}
}
Increasing the size and strength of muscles represents a promising therapeutic strategy for musculoskeletal disorders, and interest has focused on myostatin, a negative regulator of muscle growth. Various myostatin inhibitor approaches have been identified and tested in models of muscle disease with varying efficacies, depending on the age at which myostatin inhibition occurs. Here, we describe a one-time gene administration of myostatin-inhibitor-proteins to enhance muscle mass and strength in… CONTINUE READING
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Identification and characterization of a novel follistatinlike protein as a binding protein for the TGF-beta family

  • K Tsuchida
  • J Biol Chem
  • 2000
Highly Influential
6 Excerpts

Transgenic expression of a myostatin inhibitor derived from follistatin increases skeletal muscle mass and ameliorates dystrophic pathology in mdx mice

  • M Nakatani
  • FASEB J 22:477–487
  • 2008
1 Excerpt

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