Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice.

@article{SimpsonAbelson2008LongtermEA,
  title={Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice.},
  author={Michelle R. Simpson-Abelson and Gregory F Sonnenberg and Hiroshi Takita and Sandra J. Yokota and Thomas F. Conway and Raymond J. Kelleher and Leonard D Shultz and Maurice Barcos and Richard B. Bankert},
  journal={Journal of immunology},
  year={2008},
  volume={180 10},
  pages={7009-18}
}
Non-disrupted pieces of primary human lung tumor implanted into NOD-scid IL2Rgamma(null) mice consistently result in successful xenografts in which tissue architecture, including tumor-associated leukocytes, stromal fibroblasts, and tumor cells are preserved for prolonged periods with limited host-vs-graft interference. Human CD45(+) tumor-associated leukocytes within the xenograft are predominantly CD3(+) T cells with fewer CD138(+) plasma cells. The effector memory T cells that had been shown… CONTINUE READING

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