Long-term efficient gene delivery using polyethylenimine with modified Tat peptide.

@article{Yamano2014LongtermEG,
  title={Long-term efficient gene delivery using polyethylenimine with modified Tat peptide.},
  author={Seiichi Yamano and Jisen Dai and Shigeru Hanatani and Ken Haku and Takuto Yamanaka and Mika Ishioka and Tadahiro Takayama and Carlo Yuvienco and Sachin D Khapli and Amr M. Moursi and Jin Kim Montclare},
  journal={Biomaterials},
  year={2014},
  volume={35 5},
  pages={1705-15}
}
Polyethylenimine (PEI), a cationic polymer, has been widely studied and shown great promise as an efficient gene delivery vehicle. Likewise, the HIV-1 Tat peptide, a cell-permeable peptide, has been successfully used for intracellular gene delivery. To improve the favorable properties of these two vectors, we combine PEI with the modified Tat peptide… CONTINUE READING