Long-term efficacy of sertraline as a treatment for cholestatic pruritus in patients with primary biliary cirrhosis

@article{Browning2003LongtermEO,
  title={Long-term efficacy of sertraline as a treatment for cholestatic pruritus in patients with primary biliary cirrhosis},
  author={Jeff Browning and Burton Combes and Marlyn J. Mayo},
  journal={American Journal of Gastroenterology},
  year={2003},
  volume={98},
  pages={2736-2741}
}
OBJECTIVES:Generalized pruritus is a common complication of cholestatic liver diseases, although its pathogenesis remains elusive. Current treatments are often inadequate and may be poorly tolerated, so the clinician is sometimes faced with a patient in misery and no good therapeutic options. Because, in our experience, several patients with primary biliary cirrhosis (PBC) claimed that sertraline had improved their pruritus, we sought to determine whether sertraline use was associated with… CONTINUE READING