Long-term efficacy of risedronate: a 5-year placebo-controlled clinical experience.

  title={Long-term efficacy of risedronate: a 5-year placebo-controlled clinical experience.},
  author={Ole Helmer Sorensen and Gordon M. Crawford and Henk Mulder and David Hosking and Carlo Gennari and Dan Mellstrom and Simon Pack and Dietrich Wenderoth and Cyrus Cooper and J-Y. Reginster},
  volume={32 2},
Limited placebo-controlled data are available to assess the long-term fracture efficacy of bisphosphonates. In order to determine the effects of 5 years of risedronate treatment, we extended a 3-year, placebo-controlled vertebral fracture study in osteoporotic women for an additional 2 years; women who entered the extension study continued to receive 5 mg risedronate or placebo according to the original randomization, with maintenance of blinding. End points included vertebral and nonvertebral… CONTINUE READING


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