Long-term efficacy of active postexposure immunization of infants for prevention of hepatitis B virus infection. United States-People's Republic of China Study Group on Hepatitis B.

@article{Xu1995LongtermEO,
  title={Long-term efficacy of active postexposure immunization of infants for prevention of hepatitis B virus infection. United States-People's Republic of China Study Group on Hepatitis B.},
  author={Zhen-ye Xu and SWITCHINGH. Duan and H. S. Margolis and Robert H. Purcell and P Y Ou-Yang and Patrick J. Coleman and Yumei Zhuang and Hao Xu and Shi-jun Qian and Qi Rong Zhu},
  journal={The Journal of infectious diseases},
  year={1995},
  volume={171 1},
  pages={54-60}
}
Perinatal transmission of hepatitis B virus (HBV) contributes to the high prevalence of chronic infection in China and many other countries. In a placebo-controlled trial among 166 infants, the 12-month efficacy of active postexposure prophylaxis to prevent chronic perinatal HBV infection varied by vaccine (range, 45%-89%). In a 5-year follow-up study, 2 additional infants became chronically infected with HBV, and the efficacy of active prophylaxis was estimated to be 38% and 72% for the two… CONTINUE READING

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