Long term efficacy and toxicity of amiodarone in the treatment of refractory cardiac arrhythmias.

@article{Primeau1989LongTE,
  title={Long term efficacy and toxicity of amiodarone in the treatment of refractory cardiac arrhythmias.},
  author={R E Primeau and Ayman El Agha and Carla De Giorgi and Mohammad Shenasa and R{\'e}ginald Nadeau},
  journal={The Canadian journal of cardiology},
  year={1989},
  volume={5 2},
  pages={98-104}
}
Amiodarone has remarkable efficacy, but it also has a high incidence of severe side effects. Nevertheless, it is extensively used. The findings of an amiodarone treatment follow-up period of one to 72 months (mean 19 +/- 17) in 95 patients with recurrent life threatening arrhythmias resistant to other antiarrhythmic drugs are described. The mean loading dose of 800 mg/day for one week was followed by an average dose of 600 mg/day for two weeks. The long term daily dose was 400 mg in 80 patients… CONTINUE READING

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