Long-term efficacy and safety of once-daily mesalazine granules for the treatment of active ulcerative colitis

@inproceedings{Boehm2014LongtermEA,
  title={Long-term efficacy and safety of once-daily mesalazine granules for the treatment of active ulcerative colitis},
  author={Stephan Karl Boehm and Wolfgang Kruis},
  booktitle={Clinical and experimental gastroenterology},
  year={2014}
}
In 1977, 5-aminosalicylic acid (5-ASA) was discovered as a therapeutically active moiety of sulfasalazine (SASP) and was launched for topical and oral therapy of ulcerative colitis (UC) in 1984. As a first-step, delivery systems had to be developed to protect 5-ASA against absorption in the upper gastrointestinal tract, resulting in different and competing strategies (azo compounds, controlled release, and pH-dependent release). In a second step, at the beginning of the new century, coinciding… CONTINUE READING