Long-term efficacy and safety of adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B.

@article{Marcellin2008LongtermEA,
  title={Long-term efficacy and safety of adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B.},
  author={Patrick Marcellin and Ting-Tsung Chang and Seng G Lee Lim and William Sievert and M J Tong and Sarah Arterburn and Katyna Borroto-Esoda and David Frederick and Franck Rousseau},
  journal={Hepatology},
  year={2008},
  volume={48 3},
  pages={750-8}
}
UNLABELLED Treatment of 171 patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) with adefovir dipivoxil (ADV) 10 mg over 48 weeks resulted in significant histological, virological, serological, and biochemical improvement compared with placebo. The long-term efficacy and safety of ADV in a subset of these patients was investigated for up to 5 years. Sixty-five patients given ADV 10 mg in year 1 elected to continue in a long-term safety and efficacy study (LTSES). At… CONTINUE READING
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