Long-term efficacy and safety of α1 proteinase inhibitor treatment for emphysema caused by severe α1 antitrypsin deficiency: an open-label extension trial (RAPID-OLE).

@article{Mcelvaney2017LongtermEA,
  title={Long-term efficacy and safety of α1 proteinase inhibitor treatment for emphysema caused by severe α1 antitrypsin deficiency: an open-label extension trial (RAPID-OLE).},
  author={N. G. Mcelvaney and Jonathan G W Burdon and Mark D. Holmes and Allan R Glanville and Peter Alexander Blanch Wark and Philip Jean-Paul Thompson and Paul Hern{\'a}ndez and Jan Chlumsk{\'y} and Helmut Teschler and Joachim H. Ficker and Niels J{\o}rgen Seersholm and Alan Altraja and Riitta M{\"a}kitaro and joAnnA cHorostoWskA-WynIMko and Marek Sanak and Paul I Stoicescu and Eeva Piitulainen and Ondrej Vit and Marion Wencker and Michael A Tortorici and Michael A. Fries and Jonathan M. Edelman and Kenneth R Chapman},
  journal={The Lancet. Respiratory medicine},
  year={2017},
  volume={5 1},
  pages={
          51-60
        }
}
BACKGROUND Purified α1 proteinase inhibitor (A1PI) slowed emphysema progression in patients with severe α1 antitrypsin deficiency in a randomised controlled trial (RAPID-RCT), which was followed by an open-label extension trial (RAPID-OLE). The aim was to investigate the prolonged treatment effect of A1PI on the progression of emphysema as assessed by the loss of lung density in relation to RAPID-RCT. METHODS Patients who had received either A1PI treatment (Zemaira or Respreeza; early-start… CONTINUE READING
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