Long-term effects on serotonin transporter mRNA expression of chronic neonatal exposure to a serotonin reuptake inhibitor.

@article{Hansen1998LongtermEO,
  title={Long-term effects on serotonin transporter mRNA expression of chronic neonatal exposure to a serotonin reuptake inhibitor.},
  author={Henrik H. Hansen and Jens Damsgaard Mikkelsen},
  journal={European journal of pharmacology},
  year={1998},
  volume={352 2-3},
  pages={307-15}
}
Chronic administration of clomipramine or other serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitors to neonatal rats produces behaviours that resemble a depressive state in the adult animal, and this model is therefore regarded as a putative animal model of depression. Alterations in the activity of the central 5-HT system are important in understanding the pathophysiology of depression, and therefore, we examined whether this model was associated with changes in the expression of 5-HT1A… CONTINUE READING
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