Long-term effects on clinical outcomes of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation in the post coronary artery bypass graft trial. Post CABG Investigators.

@article{Knatterud2000LongtermEO,
  title={Long-term effects on clinical outcomes of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation in the post coronary artery bypass graft trial. Post CABG Investigators.},
  author={Genell L. Knatterud and Yves D Rosenberg and Lucien Campeau and Nancy L. Geller and Donald B. Hunninghake and Sandra A. Forman and James S. Forrester and Frederick L. Gobel and J. Alan Herd and Ann Hickey and Byron J Hoogwerf and Michael L Terrin and Carl W. White},
  journal={Circulation},
  year={2000},
  volume={102 2},
  pages={
          157-65
        }
}
BACKGROUND The Post Coronary Artery Bypass Graft Trial, designed to compare the effects of 2 lipid-lowering regimens and low-dose anticoagulation versus placebo on progression of atherosclerosis in saphenous vein grafts of patients who had had CABG surgery, demonstrated that aggressive lowering of LDL cholesterol (LDL-C) levels to <100 mg/dL compared with a moderate reduction to 132 to 136 mg/dL decreased the progression of atherosclerosis in grafts. Low-dose anticoagulation did not… CONTINUE READING
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