Long-term effects of selective immunolesions of cholinergic neurons of the nucleus basalis magnocellularis on the ascending cholinergic pathways in the rat: A model for Alzheimer's disease

  title={Long-term effects of selective immunolesions of cholinergic neurons of the nucleus basalis magnocellularis on the ascending cholinergic pathways in the rat: A model for Alzheimer's disease},
  author={Csaba Szigeti and Norbert Bencsik and Aurel Janos Simonka and {\'A}d{\'a}m L{\'e}gr{\'a}di and P{\'e}ter K{\'a}sa and Karoly Gulya},
  journal={Brain Research Bulletin},

The Effect of Lovastatin on the Electrophysiological Properties of CA1 Pyramidal Neurons in a Rat Model of Alzheimer Disease

The acute use of lovastatin increases the neuronal frequency in the pyramidal neurons of the CA1 region of the hippocampus in a rat model of AD.

Neurotrophin receptor p75 affords clearance of amyloid beta in Alzheimer’s disease and provides targeting route to basal forebrain cholinergic neurons

New functions of p75NTR described in this thesis make significant contribution to the knowledge of AD and can be utilized further for targeted delivery of neurotherapeutics to BFCNs with possible minimal off-side effects.

AUTEN-67 (Autophagy Enhancer-67) Hampers the Progression of Neurodegenerative Symptoms in a Drosophila model of Huntington's Disease.

It is shown that AUTEN-67 impedes the progression of neurodegenerative symptoms characterizing HD, and that autophagy is a promising therapeutic target for treating this pathology.

Cholinergic system neurochemistry toward therapeutic perspectives

Some selected concepts are mentioned as illustrative examples to put a spot light on the cholinergic system from both functional and therapeutical viewpoints.



Selective Immunolesions of Cholinergic Neurons in Mice: Effects on Neuroanatomy, Neurochemistry, and Behavior

The results indicate that a specific cholinergic immunotoxin for mice has been developed and suggest possible functional differences in the mouse and rat cholinerg systems, which may be of particular significance in attempts to develop animal models of human diseases, such as Alzheimer's disease.

Selective Lesioning of the Basal Forebrain Cholinergic System by Intraventricular 192 IgG–saporin: Behavioural, Biochemical and Stereological Studies in the Rat

The results confirm the usefulness of the 192 IgG‐saporin toxin for selective and profound lesions of the basal forebrain cholinergic neurons and provide further support for a role of theBasal forebrain Cholinergic system in cognitive functions.

Compensatory changes in cortical cholinergic innervation in the rat following an immunotoxic lesion.

Following a cholinergic-specific lesion, a compensatory mechanism is activated in the basal forebrain cholinerential system, such that surviving neurons, projecting to the same target, extend their terminals to occupy the denervated area.

Neocortical cholinergic innervation: A description of extrinsic and intrinsic components in the rat

The results indicate that approximately 70% of the cholinergic innervation in the frontoparietal cortex is derived from acetylcholinesterase positive neurons in the peripallidal nucleus basalis, whereas the remainder appears to be localized in cortical intrinsic neurons.

Differential effects on spatial navigation of immunotoxin-induced cholinergic lesions of the medial septal area and nucleus basalis magnocellularis

The data suggest that the cholinergic cortical system is critical to the performance of this spatial memory task, and an unambiguous interpretation of the anatomical locus of behavioral deficits was not possible because of damage to cholinery striatal interneurons (nBM group) and to noncholinergic cerebellar Purkinje cells (ventricular group).