Long-term effects of selective immunolesions of cholinergic neurons of the nucleus basalis magnocellularis on the ascending cholinergic pathways in the rat: A model for Alzheimer's disease
@article{Szigeti2013LongtermEO, title={Long-term effects of selective immunolesions of cholinergic neurons of the nucleus basalis magnocellularis on the ascending cholinergic pathways in the rat: A model for Alzheimer's disease}, author={Csaba Szigeti and Norbert Bencsik and Aurel Janos Simonka and {\'A}d{\'a}m L{\'e}gr{\'a}di and P{\'e}ter K{\'a}sa and Karoly Gulya}, journal={Brain Research Bulletin}, year={2013}, volume={94}, pages={9-16} }
9 Citations
The Effect of Lovastatin on the Electrophysiological Properties of CA1 Pyramidal Neurons in a Rat Model of Alzheimer Disease
- BiologyZahedan Journal of Research in Medical Sciences
- 2022
The acute use of lovastatin increases the neuronal frequency in the pyramidal neurons of the CA1 region of the hippocampus in a rat model of AD.
Neurotrophin receptor p75 affords clearance of amyloid beta in Alzheimer’s disease and provides targeting route to basal forebrain cholinergic neurons
- Biology
- 2016
New functions of p75NTR described in this thesis make significant contribution to the knowledge of AD and can be utilized further for targeted delivery of neurotherapeutics to BFCNs with possible minimal off-side effects.
Neurotrophic factors rescue basal forebrain cholinergic neurons and improve performance on a spatial learning test
- Biology, PsychologyExperimental Neurology
- 2013
Nitric oxide donor molsidomine promotes retrieval of object recognition memory in a model of cognitive deficit induced by 192 IgG-saporin
- BiologyBehavioural Brain Research
- 2019
AUTEN-67 (Autophagy Enhancer-67) Hampers the Progression of Neurodegenerative Symptoms in a Drosophila model of Huntington's Disease.
- Biology, MedicineJournal of Huntington's disease
- 2016
It is shown that AUTEN-67 impedes the progression of neurodegenerative symptoms characterizing HD, and that autophagy is a promising therapeutic target for treating this pathology.
Cholinergic system neurochemistry toward therapeutic perspectives
- Biology
- 2014
Some selected concepts are mentioned as illustrative examples to put a spot light on the cholinergic system from both functional and therapeutical viewpoints.
References
SHOWING 1-10 OF 46 REFERENCES
Selective Immunolesions of Cholinergic Neurons in Mice: Effects on Neuroanatomy, Neurochemistry, and Behavior
- BiologyThe Journal of Neuroscience
- 2001
The results indicate that a specific cholinergic immunotoxin for mice has been developed and suggest possible functional differences in the mouse and rat cholinerg systems, which may be of particular significance in attempts to develop animal models of human diseases, such as Alzheimer's disease.
Selective Lesioning of the Basal Forebrain Cholinergic System by Intraventricular 192 IgG–saporin: Behavioural, Biochemical and Stereological Studies in the Rat
- Biology, PsychologyThe European journal of neuroscience
- 1995
The results confirm the usefulness of the 192 IgG‐saporin toxin for selective and profound lesions of the basal forebrain cholinergic neurons and provide further support for a role of theBasal forebrain Cholinergic system in cognitive functions.
1921gG-saporin-induced selective lesion of cholinergic basal forebrain system: neurochemical effects on cholinergic neurotransmission in rat cerebral cortex and hippocampus
- Biology, ChemistryBrain Research Bulletin
- 1995
Selective immunolesion of cholinergic neurons leads to long-term changes in 5-HT2A receptor levels in hippocampus and frontal cortex
- Biology, PsychologyNeuroscience Letters
- 2007
Long-term effects of basal forebrain lesions on cholinergic, noradrenergic and serotonergic markers in mouse neocortex
- Biology, PsychologyBrain Research Bulletin
- 1988
Compensatory changes in cortical cholinergic innervation in the rat following an immunotoxic lesion.
- BiologyRestorative neurology and neuroscience
- 2005
Following a cholinergic-specific lesion, a compensatory mechanism is activated in the basal forebrain cholinerential system, such that surviving neurons, projecting to the same target, extend their terminals to occupy the denervated area.
Destruction of the cholinergic basal forebrain using immunotoxin to rat NGF receptor: modeling the cholinergic degeneration of Alzheimer's disease
- BiologyJournal of the Neurological Sciences
- 1995
A comparison of the distribution of central cholinergic neurons as demonstrated by acetylcholinesterase pharmacohistochemistry and choline acetyltransferase immunohistochemistry
- BiologyBrain Research Bulletin
- 1983
192IgG-saporin-induced immunotoxic lesions of cholinergic basal forebrain system differentially affect glutamatergic and GABAergic markers in cortical rat brain regions
- BiologyBrain Research
- 1995
Neocortical cholinergic innervation: A description of extrinsic and intrinsic components in the rat
- BiologyExperimental Brain Research
- 2004
The results indicate that approximately 70% of the cholinergic innervation in the frontoparietal cortex is derived from acetylcholinesterase positive neurons in the peripallidal nucleus basalis, whereas the remainder appears to be localized in cortical intrinsic neurons.