Long-term effects of sarin

@article{Sharp2006LongtermEO,
  title={Long-term effects of sarin},
  author={David Sharp},
  journal={The Lancet},
  year={2006},
  volume={367},
  pages={95-97}
}
  • D. Sharp
  • Published 14 January 2006
  • Medicine
  • The Lancet
The Tokyo subway sarin attack has long-term effects on survivors: A 10-year study started 5 years after the terrorist incident
TLDR
Although symptoms in most victims of the Tokyo subway sarin attack were transient, this large-scale follow-up data analysis revealed that survivors have been suffering from somatic and psychological long-term effects.
Mechanism of Suppression of Phagocytic and Metabolic Activity of Neutrophils and Production of Proinflammatory Cytokines during Chronic Poisoning with Organophosphorus Compounds
TLDR
Experiments on albino outbred rats showed that chronic poisoning with organophosphorus compounds (Russian VX, and sarin) for 30 days in a total dose of 0.3 DL50 (0.01 DL50 daily) is followed by a decrease in phagocytic and metabolic activity of neutrophils, which was stipulated by the stimulation of N-cholinergic receptors of these cells.
Finding New Cures for Neurological Disorders: A Possible Fringe Benefit of Biodefense Research?
  • D. Jett
  • Medicine
    Science Translational Medicine
  • 2010
TLDR
A review of recent research published by NIH investigators working in the development of therapeutic drugs to treat seizures and the neuropathology caused by chemical nerve agents indicates that scientific advances in this area have implications for reducing the burden of other neurological diseases and disorders.
Epidemiological data on health of military personnel participating in the UK’s chemical defence programme
  • D. Sharp
  • Political Science
    Journal of Epidemiology & Community Health
  • 2009
TLDR
Today the authors still need to be on their guard because of the risk of CW agents being used in acts of terrorism, but neither chemical nor biological weapons find any official support in the civilised world.
Role of Th1 and Th2 lymphocytes and cytokines produced by these cells in suppression of immune reactions during subacute poisoning with anticholinesterase toxicants
TLDR
Experiments on Wistar rats showed that subacute poisoning with anticholinesterase toxicants zarin and agent VX led to suppression of cellular and humoral immune reactions and to a decrease in blood concentrations of cytokines with a reduction of the IFN-γ/IL-4 and IL-2/ IL-4 ratios, which attests to more pronounced decrease in Th1 lymphocyte function in comparison with Th2 cells.
Ethics at Porton Down

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