Long-term effects of sarin

  title={Long-term effects of sarin},
  author={David Sharp},
  journal={The Lancet},
  • D. Sharp
  • Published 14 January 2006
  • Medicine
  • The Lancet
The Tokyo subway sarin attack has long-term effects on survivors: A 10-year study started 5 years after the terrorist incident
Although symptoms in most victims of the Tokyo subway sarin attack were transient, this large-scale follow-up data analysis revealed that survivors have been suffering from somatic and psychological long-term effects.
Mechanism of Suppression of Phagocytic and Metabolic Activity of Neutrophils and Production of Proinflammatory Cytokines during Chronic Poisoning with Organophosphorus Compounds
Experiments on albino outbred rats showed that chronic poisoning with organophosphorus compounds (Russian VX, and sarin) for 30 days in a total dose of 0.3 DL50 (0.01 DL50 daily) is followed by a decrease in phagocytic and metabolic activity of neutrophils, which was stipulated by the stimulation of N-cholinergic receptors of these cells.
Finding New Cures for Neurological Disorders: A Possible Fringe Benefit of Biodefense Research?
  • D. Jett
  • Medicine
    Science Translational Medicine
  • 2010
A review of recent research published by NIH investigators working in the development of therapeutic drugs to treat seizures and the neuropathology caused by chemical nerve agents indicates that scientific advances in this area have implications for reducing the burden of other neurological diseases and disorders.
Epidemiological data on health of military personnel participating in the UK’s chemical defence programme
  • D. Sharp
  • Political Science
    Journal of Epidemiology & Community Health
  • 2009
Today the authors still need to be on their guard because of the risk of CW agents being used in acts of terrorism, but neither chemical nor biological weapons find any official support in the civilised world.
Role of Th1 and Th2 lymphocytes and cytokines produced by these cells in suppression of immune reactions during subacute poisoning with anticholinesterase toxicants
Experiments on Wistar rats showed that subacute poisoning with anticholinesterase toxicants zarin and agent VX led to suppression of cellular and humoral immune reactions and to a decrease in blood concentrations of cytokines with a reduction of the IFN-γ/IL-4 and IL-2/ IL-4 ratios, which attests to more pronounced decrease in Th1 lymphocyte function in comparison with Th2 cells.
Ethics at Porton Down


Sarin poisoning on Tokyo subway.
Almost all patients showed miosis and related symptoms such as headache, blurred vision, or visual darkness, and although these physical signs and symptoms disappeared within a few weeks, psychologic problems associated with posttraumatic stress disorder persisted longer.
Long-term health effects of exposure to sarin and other anticholinesterase chemical warfare agents.
  • W. Page
  • Medicine
    Military medicine
  • 2003
In this study, the health effects of self-reported, nonexperimental exposure, which are subject to recall bias, were greater than thehealth effects of experimental exposure.
GB toxicity reassessed using newer techniques for estimation of human toxicity from animal inhalation toxicity data: New method for estimating acute human toxicity (GB)
Estimated human inhalation toxicity values for Sarin (GB) were calculated using a new two independent (concentration, exposure time), one dependent (toxic response), non‐linear dose response
Post‐traumatic stress disorder symptoms in victims of Tokyo subway attack: a 5‐year follow‐up study
A significant correlation between the total score of Impact of Event Scale‐Revised (IES‐R) and CAPS was found, indicating that IES‐R is a useful tool for evaluating PTSD.
Human guinea pigs
Human Guinea-Pigs: A Biography of a Family of Pigs, by Kenneth Mellanby.
Gulf War veterans and Iraqi nerve agents at Khamisiyah: postwar hospitalization data revisited.
Veterans possibly exposed to nerve agents released by the Khamisiyah demolition were not found to be at increased risk for hospitalizations from any other chronic diseases nearly 10 years after the Gulf War.
Clinical Findings In 111 Ex-Porton Down Volunteers
No evidence was found to support the hypothesis that participation in Porton Down trials produced any long-term adverse health effects or unusual patterns of disease compared to those of the general population of the same age.