Long-term effects of repeated methylamphetamine administration on dopamine and serotonin neurons in the rat brain: A regional study

@article{Ricaurte1980LongtermEO,
  title={Long-term effects of repeated methylamphetamine administration on dopamine and serotonin neurons in the rat brain: A regional study},
  author={George A. Ricaurte and Charles Roberts Schuster and Lewis S. Seiden},
  journal={Brain Research},
  year={1980},
  volume={193},
  pages={153-163}
}
Repeated high doses (25 and 100 mg/kg) of methylamphetamine produce long-term depletions of both dopamine (DA) and serotonin (5-HT) in the rat brain. In the DA system, depletions are most pronounced in the neostriatum and substantia nigra, with decreased levels in these two regions being significantly correlated. Within the 5-HT system, levels are most reduced in the amygdala, frontal cortex and neostriatum. When both the DA and 5-HT depleting actions of methylamphetamine are considered, the… CONTINUE READING
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