Long-term effects of portacaval anastomosis on the 5-hydroxytryptamine, histamine, and catecholamine neurotransmitter systems in rat brain.

@article{Lozeva1998LongtermEO,
  title={Long-term effects of portacaval anastomosis on the 5-hydroxytryptamine, histamine, and catecholamine neurotransmitter systems in rat brain.},
  author={Violina Lozeva and E. Macdonald and A Belcheva and Mikko Hippel{\"a}inen and H. Kosunen and Leena M Tuomisto},
  journal={Journal of neurochemistry},
  year={1998},
  volume={71 4},
  pages={1450-6}
}
Portacaval anastomosis (PCA) in the rat is used as a model for portal systemic encephalopathy. Changes in the serotonergic, histaminergic, and catecholaminergic neurotransmitter systems are often found shortly after PCA. We have examined the long-term effects of PCA on the aminergic systems in brains of male Wistar rats, which 8 months previously had been subjected to PCA. Precursors, amines, and metabolites were assayed by HPLC. Eight months after PCA, the catecholamine levels were unchanged… CONTINUE READING