Long-term effects of percutaneous estradiol on bone loss and bone metabolism in postmenopausal hysterectomized women.


OBJECTIVE To determine whether percutaneous estradiol (pE2) (1.5 mg/day) is able to counteract the postmenopausal bone loss in postmenopausal hysterectomized women, in a double-blind study versus oral estriol (E3) (2 mg/day). METHODS The bone mineral density of the lumbar spine (LS) and of the proximal femur (PF) was measured every 3 months by dual energy… (More)


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