Long-term effects of ovariectomy and estrogen replacement treatment on endothelial function in mature rats.

@article{MoienAfshari2003LongtermEO,
  title={Long-term effects of ovariectomy and estrogen replacement treatment on endothelial function in mature rats.},
  author={Farzad Moien-Afshari and Emma J. Kenyon and Jonathan C. Choy and Bruno Battistini and Bruce McManus and Ismail Laher},
  journal={Maturitas},
  year={2003},
  volume={45 3},
  pages={
          213-23
        }
}
OBJECTIVES Estrogen replacement therapy (ERT) improves blood flow through various mechanisms including an augmented release of nitric oxide (NO). We report on the long-term effects of estrogen loss on vascular function and endothelial regulation. METHODS Male, female, ovariectomized and ovariectomized+ERT treated rats were used. Female rats were ovariectomized at 12 weeks of age and received ERT via subcutaneously implanted 90-day release pellets. Vasodilation to acetylcholine (ACh) was… CONTINUE READING
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