Long-term effects of nifedipine on plasma levels of 25 hydroxyvitamin D and 1,25 dihydroxyvitamin D in hypertensive hemodialyzed patients

Abstract

Recent studies of Baran and Milne [2] indicate that calcium ion inhibits 25-OH-D synthesis in rat liver homogenates in a dose-dependent fashion. Furthermore, the calcium ionophore A23187, which also increases cytosolic calcium, inhibits hepatocyte 25-OH-D production [2]. It has been shown that 1,25-(OH)2-D inhibits 25-OH-D production [1]. This vitamin D metabolite also increases hepatocyte cytosolic calcium levels [2]. We have investigated the effects of the calcium-channel blocker nifedipine on serum 25-OH-D and 1,25-(OH)2-D levels in hypertensive patients undergoing RDT.

DOI: 10.1007/BF01785712

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Cite this paper

@article{Riegel1986LongtermEO, title={Long-term effects of nifedipine on plasma levels of 25 hydroxyvitamin D and 1,25 dihydroxyvitamin D in hypertensive hemodialyzed patients}, author={Werner Riegel and Walter Hermann H{\"{o}rl and August Heidland}, journal={Klinische Wochenschrift}, year={1986}, volume={64}, pages={1291-1291} }