• Corpus ID: 20186674

Long term effects of monosodium glutamate on spermatogenesis following neonatal exposure in albino mice--a histological study.

@article{Das2010LongTE,
  title={Long term effects of monosodium glutamate on spermatogenesis following neonatal exposure in albino mice--a histological study.},
  author={R S Das and S K Ghosh},
  journal={Nepal Medical College journal : NMCJ},
  year={2010},
  volume={12 3},
  pages={
          149-53
        }
}
Monosodium glutamate (MSG), popularly known as Azinomoto has been in use since long as a flavour enhancing substance. Its widespread use has also earned it a bad name as hazardous for human health. It has been incriminated to cause wide range of effects comprising retinal degeneration, metabolic disorders, endocrinal disorders including reduced fertility rate in both male and female experimental mice and rats following neonatal exposure. However there are many contradicting views too regarding… 
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23 Citations
Highly Influential Citations
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Background Citations
11
Results Citations
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23 Citations

EFFECT OF GINGER ON TESTICULAR TISSUE OF ADULT MALE ALBINO RATS TREATED WITH MONO SODIUM GLUTAMATE (LIGHT AND ELECTRON MICROSCOPIC STUDIES)

Ginger has protective effects against MSG on the rat testicular tissue and the testicular damage caused by MSG is reversible without treatment or with administration of Ginger.

Effects of Monosodium Glutamate on the Liver of Male Adult Albino Rat and the Possible Protective Role of Vitamin C (Light and Electron Microscopic Study)

Study of the potential protective effect of Vitamin C on liver damage caused by monosodium glutamate in adult male rats found it decreased those toxic effects of MSG.

Ingestion of monosodium glutamate (MSG) in adult male rats reduces sperm count, testosterone, and disrupts testicular histology

Adult intake of MSG can negatively impact sperm count and serum testosterone concentrations as well as testicular morphology and histology in rats and further investigation of this effect should be evaluated in humans for such a popular flavor enhancer.

Effect of monosodium glutamate on serum sex hormones and uterine histology in female rats along with its molecular docking and in-silico toxicity

Effect of different doses of monosodium glutamate on the thyroid follicular cells of adult male albino rats: a histological study.

  • H. KhalafE. Arafat
  • Biology, Medicine
    International journal of clinical and experimental pathology
  • 2015
The results displayed that MSG even at low doses is capable of producing alterations in the body weights and thyroid tissue function and histology.

Monosodium glutamate suppresses the female reproductive function by impairing the functions of ovary and uterus in rat

It is concluded that MSG suppresses the female reproductive function in rat probably by impairing the functions of ovary and uterus.

AMELIORATIVE EFFECT OF DILTIAZEM ON THE MONOSODIUM GLUTAMATE TREATED STROMA OF FALLOPIAN TUBE AND SERUM ESTROGEN LEVELS

The findings obtained from the study after administration of MSG and diltiazem showed stromal vacuolations in the fallopian tube of rat leading to change in its functional aspect and impairing the female fertility while treatment with diltsiazem prevents these effects.

L-Glutamic acid monosodium salt reduces the harmful effect of lithium on the development of Xenopus laevis embryos

Examination of the developmental effects of exposure to flavor enhancer MSG and LiCI medicament on Xenopus embryos using the frog embryo teratogenesis assay of Xenopus test found MSG attenuated harmful effects of Li in MSG+Li combined treatments and Li-involving treatments caused dramatic deleterious effects.

INFLUENCE OF SELENIUM ON MONO SODIUM GLUTAMATE AS FOOD ADDITIVE INDUCED HEPATOTOXICITY AND TESTICULAR TOXICITY IN ADULT ALBINO RATS

Administration of Se along with MSG produced partial improvement of hepatic and testicular morphological changes, reduction in caspase 3 expression with beneficial effect on liver andtesticular parameters, andSelenium has partial protective effects against MSG induced hepatic, testicular toxicity through its anti oxidant and its anti apoptotic effects.

Monosodium Glutamate (MSG)-Induced Male Reproductive Dysfunction: A Mini Review

Various established mechanisms through which MSG may induce reproductive dysfunction and the treatment strategies to ameliorate its toxic effects are discussed.

18 References

Monosodium glutamate disruption of behavioral and endocrine function in the female rat.

The findings that chronic estrogen followed by progesterone treatment can reinstate sexual receptivity in MSG-treated animals suggests that the arcuate nuclei are not needed for the expression of sexual behavior and that estrogens might remedy the fertility problems of MSG- treated animals.

Effects of neonatal treatment with MSG (monosodium glutamate) on hypothalamo-pituitary-thyroid axis in adult male rats.

The results obtained suggest that the rat hypothalamic centres involved in regulation of the pituitary-thyroid axis are slightly affected by neonatal MSG treatment, leading to a syndrome of endocrine dysfunction characterised by reduced growth, obesity and hypogonadism.

The safety evaluation of monosodium glutamate.

A subsequent review by the Federation of American Societies for Experimental Biology and the Federal Drug Administration did not discount the existence of a sensitive subpopulation but otherwise concurred with the safety evaluation of JECFA and the SCF.

Late endocrine effects of administering monosodium glutamate to neonatal rats.

Persistent alterations in neuroendocrine function indicate that lesions produced by neonatal MSG treatment provide a convenient model for studying hypothalamic function.

Monosodium glutamate admlinistration to the newborn reduces reproductive ability in female and male mice.

Monosodium glutamate (MSG) administered during the neonatal period (days 2 to 11) resulted in a sequence of events that were manifested in adulthood. Reproductive dysfunction was seen in both female…

Monosodium glutamate in standard and high-fiber diets: metabolic syndrome and oxidative stress in rats.

Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate

It is postulated that the aduls syndrome represents a multifacted nueroendocrine disturbance arising from the disruption of developing nueral centers concered in the mediation of endocrine function.

Effect of monosodium glutamate on some endocrine functions.

Neonatal female and male rats of the Sprague-Dawley strain were injected subcutaneously with a daily dose of MSG beginning on the 2nd day of life and autopsied at 40 days of life.

Glutamic acid, twenty years later.

This review examines progress in understanding the physiologic functions of glutamic acid in the body since the first symposium on glutamic acid physiology and biochemistry was held at the Mario…

Quantitative parameters for light microscopic assessment of the tubuli seminiferi.