Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.

@article{Schmidt2001LongtermEO,
  title={Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.},
  author={Barbara K Schmidt and Peter G Davis and Dianne Moddemann and Arne Ohlsson and R. S. Roberts and Saroj Saigal and Alfonso J Solimano and Michael J. Vincer and Linda L. Wright},
  journal={The New England journal of medicine},
  year={2001},
  volume={344 26},
  pages={1966-72}
}
BACKGROUND The prophylactic administration of indomethacin reduces the frequency of patent ductus arteriosus and severe intraventricular hemorrhage in very-low-birth-weight infants (those with birth weights below 1500 g). Whether prophylaxis with indomethacin confers any long-term benefits that outweigh the risks of drug-induced reductions in renal, intestinal, and cerebral blood flow is not known. METHODS Soon after they were born, we randomly assigned 1202 infants with birth weights of 500… CONTINUE READING