Long-term effects of elevated gastrin levels on calcitonin secretion

@article{Erdoan2006LongtermEO,
  title={Long-term effects of elevated gastrin levels on calcitonin secretion},
  author={Murat Faik Erdoğan and Alptekin Gursoy and Mustafa Kulaksızoğlu},
  journal={Journal of Endocrinological Investigation},
  year={2006},
  volume={29},
  pages={771-775}
}
Gastrin and pentagastrin stimulate thyroid C cells and elevate serum calcitonin levels. Gastrin levels may be elevated when histamine-2 receptor blockers (H2RB) and/or proton pump inhibitors (PPI) are used, or in patients with pernicious anemia (PA). This study was designed to investigate the long-term effects of elevated gastrin levels on serum calcitonin levels. We conducted a pentagastrin stimulation test to evaluate C cell reserves in patients who had been using PPI and/or H2RB for an… 
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There is not enough information from patients with diabetes or tissue samples from subjects treated with GLP-1R agonists and related drugs—especially data obtained during the prandial period or from a long-term study, therefore, it is important to focus on the possible side effects of GLp-1r agonists on thyroid C cells.
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It is suggested that increases of plasma iCT concentrations after administration of pentagastrin in man reflect pharmacologic phenomena and that postprandial gastrin secretion may be insufficient to affect peripheral i CT concentrations.
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TLDR
It is suggested that chronically elevated endogenous gastrin is without influence on calcitonin secretion, and suppression of endogenous Gastrin secretion in 5 of the patients by intragastric acid administration was not accompanined by any decrease in calciton in serum.
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TLDR
The results indicate that serum gastrin is without influence on calcitonin release, either in hypergastrinaemic patients with pernicious anaemia or in healthy subjects.
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The results suggest that the stimulation of calcitonin secretion by gastrin and its synthetic analogue pentagastrin is a pharmacological rather than a physiological phenomenon.
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TLDR
It is concluded that chronically elevated serum gastrin levels do not result in hypercalcitoninaemia, since serum calcitonin was normal in 12 normogastrinaemic patients with hyperparathyroidism from families with multiple endocrine adenomatosis type 1.
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TLDR
The data show that administration of therapeutic doses of traditional H2-antagonists is accompanied by a secondary hypergastrinemia, which is rapidly reversible after discontinuation of therapy, in addition to confirming the well-known effect of omeprazole on the physiology of gastric secretion.
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TLDR
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TLDR
Exogenous gastrin release achieved by omeprazole is used as a new, safe, cheap, and outpatient-basis test for MTC diagnosis, follow-up, and screening and showed a steady and significant increase in GT and CT levels.
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TLDR
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TLDR
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