Long term effects of dichloromethylene diphosphonate in Paget's disease of bone.

@article{Delmas1982LongTE,
  title={Long term effects of dichloromethylene diphosphonate in Paget's disease of bone.},
  author={Pierre Dominique Delmas and Marie Claire Chapuy and Eric P. Vignon and S A Charhon and Daniel Briançon and Catherine Alexandre and Claude M. Edouard and Pierre Jean Meunier},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1982},
  volume={54 4},
  pages={837-44}
}
Dichloromethylene diphosphonate (Cl2MDP) is a diphosphonate which markedly inhibits bone resorption. We have tested Cl2MDP in Paget's disease, a disorder characterized by increased bone remodeling. Sixty-three patients with progressive Paget's disease were treated for 6 months with Cl2MDP at daily oral doses of 400, 800, 1600, or 2400 mg. Thirty-nine patients received calcium and vitamin D supplements during treatment. patients in all treatment groups had significant reduction in serum alkaline… CONTINUE READING

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