Long-term effects of constant light or darkness on chicken pineal hydroxyindole-O-methyltransferase expression: biochemical and cellular aspects

@article{Guerlott1992LongtermEO,
  title={Long-term effects of constant light or darkness on chicken pineal hydroxyindole-O-methyltransferase expression: biochemical and cellular aspects},
  author={J{\'e}r{\^o}me Guerlott{\'e} and Pierre J Voisin and Marianne Bernard and Paul A. Brisson and Jack Falc{\'o}n and J. L. Blasquez and J. -P. Collin},
  journal={Cellular and Molecular Neurobiology},
  year={1992},
  volume={12},
  pages={177-184}
}
1. Chickens kept in constant light, as opposed to constant darkness, display a twofold increase in the activity of pineal hydroxyindole-O-methyltransferase (HIOMT), the last acting enzyme in the melatonin pathway. 2. Using an immunological approach, we presently show that this regulation of HIOMT activity reflects changes in the concentration of a single molecular form of the enzyme protein (a 38 kDa polypeptide). Immunohistofluorescence indicates that these concentration changes concurrently… CONTINUE READING