Long-term effects of chronic nicotine on emotional and cognitive behaviors and hippocampus cell morphology in mice: comparisons of adult and adolescent nicotine exposure.

@article{Holliday2016LongtermEO,
  title={Long-term effects of chronic nicotine on emotional and cognitive behaviors and hippocampus cell morphology in mice: comparisons of adult and adolescent nicotine exposure.},
  author={Erica D Holliday and Paul Nucero and Munir Gunes Kutlu and Chicora F Oliver and Krista L. Connelly and Thomas J Gould and Ellen M. Unterwald},
  journal={The European journal of neuroscience},
  year={2016},
  volume={44 10},
  pages={
          2818-2828
        }
}
Nicotine dependence is associated with increased risk for emotional, cognitive and neurological impairments later in life. This study investigated the long-term effects of nicotine exposure during adolescence and adulthood on measures of depression, anxiety, learning and hippocampal pyramidal cell morphology. Mice (C57BL/6J) received saline or nicotine for 12 days via pumps implanted on postnatal day 32 (adolescent) or 54 (adults). Thirty days after cessation of nicotine/saline, mice were… CONTINUE READING
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