Long-term effects of chronic nicotine exposure on brain nicotinic receptors.

@article{Besson2007LongtermEO,
  title={Long-term effects of chronic nicotine exposure on brain nicotinic receptors.},
  author={Morgane Besson and Sylvie Granon and Monica Mameli-Engvall and Isabelle Clo{\"e}z-Tayarani and Nicolas Maubourguet and Anne Cormier and Pierre Cazala and Vincent David and Jean-Pierre Changeux and Philippe Faure},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 19},
  pages={8155-60}
}
Chronic nicotine exposure results in long-term homeostatic regulation of nicotinic acetylcholine receptors (nAChRs) that play a key role in the adaptative cellular processes leading to addiction. However, the relative contribution of the different nAChR subunits in this process is unclear. Using genetically modified mice and pharmacological manipulations, we provide behavioral, electrophysiological, and pharmacological evidence for a long-term mechanism by which chronic nicotine triggers… CONTINUE READING
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