Long-term effects of chronic methamphetamine administration in rhesus monkeys.

  title={Long-term effects of chronic methamphetamine administration in rhesus monkeys.},
  author={William L. Woolverton and George A. Ricaurte and Lysia S. Forno and Lewis S. Seiden},
  journal={Brain research},
  volume={486 1},
Biochemical and neuropathological effects of exposure to a high dose regimen of methamphetamine were evaluated in rhesus monkeys approximately 4 years after the last drug injection. Concentrations of dopamine and serotonin in caudate were below control levels as were concentrations of serotonin in several other brain regions. These changes were more severe in a monkey that was exposed twice to the drug regimen. A decrease in caudate synaptosomal uptake of both neurotransmitters as well as… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 73 extracted citations

Support for selection of a methamphetamine cleanup standard in Colorado.

Regulatory toxicology and pharmacology : RTP • 2007
View 4 Excerpts
Highly Influenced

Brain serotonin transporter in human methamphetamine users

Psychopharmacology • 2008
View 5 Excerpts
Highly Influenced

Why is parkinsonism not a feature of human methamphetamine users?

Brain : a journal of neurology • 2004
View 1 Excerpt
Highly Influenced

Recovery of presynaptic dopaminergic functioning in rats treated with neurotoxic doses of methamphetamine.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1999
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…