Long-term effects of chronic methamphetamine administration in rhesus monkeys.

@article{Woolverton1989LongtermEO,
  title={Long-term effects of chronic methamphetamine administration in rhesus monkeys.},
  author={William L. Woolverton and George A. Ricaurte and Lysia S. Forno and Lewis S. Seiden},
  journal={Brain research},
  year={1989},
  volume={486 1},
  pages={73-8}
}
Biochemical and neuropathological effects of exposure to a high dose regimen of methamphetamine were evaluated in rhesus monkeys approximately 4 years after the last drug injection. Concentrations of dopamine and serotonin in caudate were below control levels as were concentrations of serotonin in several other brain regions. These changes were more severe in a monkey that was exposed twice to the drug regimen. A decrease in caudate synaptosomal uptake of both neurotransmitters as well as… CONTINUE READING

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