Long-term effects of caffeine therapy for apnea of prematurity.

  title={Long-term effects of caffeine therapy for apnea of prematurity.},
  author={Barbara Schmidt and Robin S. Roberts and Peter Graham Davis and Lex William Doyle and Keith James Barrington and Arne Ohlsson and Alfonso J Solimano and Win Tin},
  journal={The New England journal of medicine},
  volume={357 19},
BACKGROUND Methylxanthine therapy is commonly used for apnea of prematurity but in the absence of adequate data on its efficacy and safety. It is uncertain whether methylxanthines have long-term effects on neurodevelopment and growth. METHODS We randomly assigned 2006 infants with birth weights of 500 to 1250 g to receive either caffeine or placebo until therapy for apnea of prematurity was no longer needed. The primary outcome was a composite of death, cerebral palsy, cognitive delay… 

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