Long-term effects of bone marrow transplantation in dogs with mucopolysaccharidosis I.

@article{Breider1989LongtermEO,
  title={Long-term effects of bone marrow transplantation in dogs with mucopolysaccharidosis I.},
  author={Michael A. Breider and Robert M Shull and George C Constantopoulos},
  journal={The American journal of pathology},
  year={1989},
  volume={134 3},
  pages={677-92}
}
The therapeutic effects of allogeneic bone marrow transplantation (BMT) in a canine model of mucopolysaccharidosis I (MPS I) were investigated. Long-term post-BMT pathologic and biochemical studies were performed on three groups of dogs: 1) MPS I-affected dogs that did not receive BMT, 2) MPS I-affected dogs that received total body irradiation followed by an allogeneic BMT, and 3) normal, unaffected dogs that served as BMT donors. All dogs were necropsied at approximately 20 months after BMT… CONTINUE READING