Long-term effects of HIV-1 protease inhibitors on insulin secretion and insulin signaling in INS-1 beta cells.

@article{Schtt2004LongtermEO,
  title={Long-term effects of HIV-1 protease inhibitors on insulin secretion and insulin signaling in INS-1 beta cells.},
  author={Morten Sch{\"u}tt and Jiang-liang Zhou and Marit Meier and Harald H. Klein},
  journal={The Journal of endocrinology},
  year={2004},
  volume={183 3},
  pages={445-54}
}
The mechanism by which chronic treatment with HIV (human immunodeficiency virus)-1 protease inhibitors leads to a deterioration of glucose metabolism appears to involve insulin resistance, and may also involve impaired insulin secretion. Here we investigated the long-term effects of HIV-1 protease inhibitors on glucose-stimulated insulin secretion from beta cells and explored whether altered insulin secretion might be related to altered insulin signaling. INS-1 cells were incubated for 48 h… CONTINUE READING

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