Long-term effects of BRAF inhibitors in melanoma treatment: friend or foe?

@article{Sloot2014LongtermEO,
  title={Long-term effects of BRAF inhibitors in melanoma treatment: friend or foe?},
  author={Sarah Sloot and Inna V. Fedorenko and Keiran S. M. Smalley and Geoffrey Thomas Gibney},
  journal={Expert Opinion on Pharmacotherapy},
  year={2014},
  volume={15},
  pages={589 - 592}
}
The clinical development of selective BRAF inhibitors for metastatic BRAF V600 mutant melanoma patients has been a major breakthrough in targeted therapeutics. Objective response rates of approximately 50% have been observed in the Phase III studies of the BRAF inhibitors vemurafenib and dabrafenib. The side effects can be relatively common, including proliferative skin toxicities. The latter range from hyperkeratosis and keratoacanthomas (KAs) to squamous cell carcinomas (SCCs) and new primary… 
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