Long-term effect of nonsteroidal anti-inflammatory drugs on the production of cytokines and other inflammatory mediators by blood cells of patients with osteoarthritis

@article{Gonzalez1994LongtermEO,
  title={Long-term effect of nonsteroidal anti-inflammatory drugs on the production of cytokines and other inflammatory mediators by blood cells of patients with osteoarthritis},
  author={Eli Gonzalez and Carlos M Cruz and Rosario de Nicolas and Jes{\'u}s Egido and G Herrero-Beaumont},
  journal={Agents and Actions},
  year={1994},
  volume={41},
  pages={171-178}
}
Most of the previous studies dealing with the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on the synthesis of inflammatory mediators involved in joint damage have been done in cells culturedin vitro or in blood cells from patients treated for short periods of time. In this work we have evaluated the long-term effect of aceclofenac, a new NSAID, and diclofenac on the production of a series of inflammatory mediators by blood cells from 30 patients with severe knee osteoarthritis. Both… CONTINUE READING

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Most of the previous studies dealing with the effect of nonsteroidal anti - inflammatory drugs ( NSAIDs ) on the synthesis of inflammatory mediators involved in joint damage have been done in cells culturedin vitro or in blood cells from patients treated for short periods of time .
Most of the previous studies dealing with the effect of nonsteroidal anti - inflammatory drugs ( NSAIDs ) on the synthesis of inflammatory mediators involved in joint damage have been done in cells culturedin vitro or in blood cells from patients treated for short periods of time .
In this work we have evaluated the long - term effect of aceclofenac , a new NSAID , and diclofenac on the production of a series of inflammatory mediators by blood cells from 30 patients with severe knee osteoarthritis .
In this work we have evaluated the long - term effect of aceclofenac , a new NSAID , and diclofenac on the production of a series of inflammatory mediators by blood cells from 30 patients with severe knee osteoarthritis .
In this work we have evaluated the long - term effect of aceclofenac , a new NSAID , and diclofenac on the production of a series of inflammatory mediators by blood cells from 30 patients with severe knee osteoarthritis .
Interleukin-6 ( IL-6 ) synthesis was not affected by aceclofenac while it was diminished by diclofenac .
In this work we have evaluated the long - term effect of aceclofenac , a new NSAID , and diclofenac on the production of a series of inflammatory mediators by blood cells from 30 patients with severe knee osteoarthritis .
Both aceclofenac and diclofenac significantly inhibited prostaglandin E2 ( PGE2 ) synthesis by blood mononuclear and polymorphonuclear cells after 180 days of treatment .
However , no clear effect was noted on leukotriene B4 ( LTB4 ) and platelet activating factor ( PAF ) production .
However , no clear effect was noted on leukotriene B4 ( LTB4 ) and platelet activating factor ( PAF ) production .
In this work we have evaluated the long - term effect of aceclofenac , a new NSAID , and diclofenac on the production of a series of inflammatory mediators by blood cells from 30 patients with severe knee osteoarthritis .
In this work we have evaluated the long - term effect of aceclofenac , a new NSAID , and diclofenac on the production of a series of inflammatory mediators by blood cells from 30 patients with severe knee osteoarthritis .
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