• Corpus ID: 38731114

Long term effect of monosodium glutamate in liver of albino mice after neonatal exposure

@inproceedings{Bhattacharya2011LongTE,
  title={Long term effect of monosodium glutamate in liver of albino mice after neonatal exposure},
  author={Tapati Bhattacharya and Abhijit Bhakta and S.K. Ghosh},
  year={2011}
}
Mono Sodium Glutamate (MSG) is a naturally occurring excitatory neurotransmitter. It is extensively used as a food additive and flavoring agent for its UMAMI taste. Simaltaneously it is being implicated for varied pathological condition like obesity, gonadal dysfunction, learning difficulty etc. It produces oxygen derived free radicals and metabolized in liver. Neonate mice are sensitive and suffer from adverse effects. Present work was undertaken to study the long term effects on histology of… 
nmcth.edu
27 Citations
Highly Influential Citations
3
Background Citations
4
Methods Citations
1
Results Citations
5

Figures from this paper

27 Citations

Effects of Monosodium Glutamate on the Liver of Male Adult Albino Rat and the Possible Protective Role of Vitamin C (Light and Electron Microscopic Study)

Study of the potential protective effect of Vitamin C on liver damage caused by monosodium glutamate in adult male rats found it decreased those toxic effects of MSG.

Effect of monosodium glutamate on liver of pregnant rats and their fetuses (Histological and histochemical studies)

This study showed that short-term MSG exposure in the gestational periods caused several histological and histochemical changes in the maternal and fetal liver tissues.

Effects of chronic oral monosodium glutamate on body weight and liver histology in Wistar rats

The findings suggest that chronic intake of high doses of GMS may affect rat livers, and this work is concerned with Wistar male rats, which are known to have low livers responsive to GMS.

Effect of Monosodium Glutamate on Chick Embryo Development

It was concluded that a single low dose of monosodium glutamate might affect chick embryonic development causing growth retardation, congenital malformations, and liver degeneration.

Effect of Monosodium Glutamate (MSG) On Tissue and Function of Liver and Kidney and Body Weight in Male Albino Mice

The results showed significance increase in the body weight in MSG treated group compared to the control group, MSG cause increases in liver and kidney weight in treated groupCompared to thecontrol group, and also the urea and creatinine increased in experimental group comparedto control group.

Adverse cytological and enzymatic effects of long term Monosodium glutamate (MSG) intake on liver

The high uptake of MSG for a long duration may lead to obesity and induce adverse effects on liver tissue, increase hepatocytes proliferation which may Lead to cancer and May lead to increase liver biomarker.

The Effect of Nigella Sativa Extract on Alpha-ketoglutarate Activity and Histopathologic Changes on Rat Liver Induced by Monosodium Glutamate

Investigation of different Doses of Nigella sativa on alpha KGDH activity and liver histology of MSG induced rat showed that administration of MSG increase alphaKGDH and induced damage in liver tissue, which showed Nigella sitiva extract can reduce alpha KgDH and prevent liver damage induced by MSG.

Effect of diltiazem and quercetin on monosodium glutamate-induced hepatic dysfunction in rats

Diltiazem and quercetin reduce hepatic oxidative stress and tissue damage induced by MSG, and improve liver dysfunctions, with better effect of their combination.

HISTOLOGICAL & HISTOCHMICAL CHANGES IN LIVER OF ADULT RATS TREATED WITH MONOSODIUM GLUTAMATE: A LIGHT MICROSCOPIC STUDY

The findings revealed that there were deleterious changes in the liver tissue such as dilated and congested central vein, inflammatory cell infiltration, cytoplasmic vaculation and pyknotic nucleus, cyto architecture.

Cytotoxic effect of monosodium glutamate (MSG) on hepatocytes of Mus musculus

Investigation of the effect of MSG on hepatic cells of Mus musculus revealed drastic changes found in cellular architecture of liver tissues leading to different physiological symptoms, which were discussed in relation to hepato-toxicity and relevent metabolism.

26 References

The safety evaluation of monosodium glutamate.

A subsequent review by the Federation of American Societies for Experimental Biology and the Federal Drug Administration did not discount the existence of a sensitive subpopulation but otherwise concurred with the safety evaluation of JECFA and the SCF.

Histochemical Studies of the Effects of Monosodium Glutamate on the Liver of Adult Wistar Rats

The findings showed that monosodium glutamate consumption may have some deleterious effects on the liver of adult Wistar rats at higher doses and by extension may affect the functions of the liver.

Monosodium glutamate-induced damage in liver and kidney: a morphological and biochemical approach.

Brain Damage in Infant Mice following Oral Intake of Glutamate, Aspartate or Cysteine

It is found that a similar process of acute neuronal necrosis occurs in several regions of the infant mouse brain after subcutaneous treatment with MSG, and that animals treated with high doses in infancy tend to manifest obesity and neuroendocrine disturbances as adults.

Studies on the effect of monosodium glutamate [MSG] administration on some antioxidant enzymes in the arterial tissue of adult male mice.

The subcutaneous administration of monosodium glutamate to normal adult male mice at dose levels of 4 and 8 mg/g body weight caused a significant increase in lipid peroxidation level in the arterial…

Studies on brain lesions after administration of monosodium L-glutamate to mice. II. Absence of brain damage following administration of monosodium L-glutamate in the diet.

Morphological and cell proliferative study on the growth of visceral organs in monosodium L-glutamate-treated obese mice.

In the MSG-treated mice with specific growth patterns of visceral organs, it is suggested that low energy expenditure results in a relatively excessive energy supply and leads to obesity, because most of the important organs with major physiological functions became hypoplastic.

Effects of ethanol ingestion on the hepatotoxicity and metabolism of paracetamol in mice.

Age dependent sensitivity to monosodium glutamate inducing brain damage in the chicken.

It is suggested that the decrease in the of the domestic fowl to M.S.G. inducing brain damage is age dependent being probably as a result of the development of a blood-brain-barrier to glutamic acid.

The uptake of glutamic acid and glutamine by brain and other tissues of the rat and mouse.