Long-term effect of benzene in C57BL/6N mice.

  title={Long-term effect of benzene in C57BL/6N mice.},
  author={J. Ward and J. Weisburger and R. S. Yamamoto and T. Benjamin and C. Brown and E. Weisburger},
  journal={Archives of environmental health},
  volume={30 1},
Weaning male C57BL/6N mice received repeated subcutaneous injections of benzene in corn oil for 54 weeks. These mice and surviving controls were killed 104 weeks after the first injection. There was no evidence of carcinogenic activity in benzene-injected mice. A high incidence of amyloidosis developed in mice of all treated and untreated groups. Butyinitrosourea, used as a positive control, induced lymphomas or leukemias (in most exposed mice) and intestinal tumors in a few. 
Benzene inhalation produces leukemia in mice.
Female C57Bl/6 mice were exposed to 300 ppm benzene 6 hr/day, 5 days/week for 16 weeks and then held for lifetime observation to provide proof of the leukemogenicity of benzene in female C57 Bl/ 6 mice. Expand
The inhalation toxicology of benzene: incidence of hematopoietic neoplasms and hematotoxicity in ARK/J and C57BL/6J mice.
The benzene exposures did not alter the incidence or induction time of the viral-induced lymphomas commonly seen in AKR mice, but there was a significant increase in the incidence of hematopoietic neoplasms including six cases of thymic lymphoma in benzene-exposed C57BL mice. Expand
The detection of in vivo hematotoxicity of benzene by in vitro liquid bone marrow cultures.
It is indicated that benzene inhalation produces stem cell injury leading to diminished self-replication and derangement of the adherent marrow population, and neonatal mice inoculated with cultured cells from benzene-exposed mice have not developed leukemia during an 8-month period after inoculation. Expand
Chemically induced leukemia in humans.
Several important problems exist with regard to implicating specific agents in the development of this neoplasm in man, including the paucity of animal models for chemically induced leukemia, and the frequent necessity to rely on single case reports or clusters of cases in which chemical exposures are associated with acute leukemia. Expand
Bone marrow depressant and leukemogenic actions of benzene.
Current ideas on the mechanisms by which benzene may produce leukemias and aplastic anemia are explored and recent work suggesting that the causative agent is a metabolite of benzene is emphasized. Expand
Mechanisms of Benzene Toxicity
Benzene is a ubiquitous pollutant in the environment and in many workplaces. It is known to produce aplastic anemia, leukemia, chromosomal damage, and immunotoxicity. This discussion will considerExpand
Chemical of Current Interest-Benzene
  • W. Marcus
  • Chemistry, Medicine
  • Toxicology and industrial health
  • 1987
The study will summarize the exposure of the population to benzene with emphasis on exposure through water and take advantage of the benzene literature as it currently exists, although it is known that ben zene can be absorbed via the GI tract. Expand
Tumors of the mouse hematopoietic system: their diagnosis and interpretation in safety evaluation tests. Report of a study group.
A nomenclature for tumors of the mouse hematopoietic system is proposed. This nomenclature, which will be particularly appropriate for use in safety assessment studies, employs basic cytologicExpand
An evaluation of the associations of leukemia and rubber industry solvent exposures.
Data from a small case-control study of lymphocytic leukemia are presented to illustrate an approach that considers multiple solvent exposures, and associations with lymphocytics leukemia risk observed for a number of solvents were stronger than those detected for benzene. Expand
Benzene Related Hematological Disorders: Evidence for a Threshold in Animals and Humans
A large number of the studies conducted in this Investigation found that under-chronic Toxicity in Animals and Carcinogenicity in Animals is higher than in Human Studies with Quantitative Exposure Measurements, and evidence for a Threshold Dose is provided using the Hill Criteria. Expand


The hemopoietic tissue toxicity of benzene vapors.
The data presented here indicate that benzene vapors have greater hemopoietic tissue toxicity than is commonly recognized, and it seems advisable to consider reevaluation of the Maximum Allowable Concentration of 25 ppm. Expand
The induction of tumours in the rat by a single oral dose of N-nitrosomethylurea.
ImagesFigs. 6-7Figs. 8-9Figs. 10-11Figs. 2-5
A painter who was exposed to benzene for 13 years developed a hypocellular bone marrow and pancytopenia, which was found to be characteristic of acute myelogenous leukemia. Expand
Occupational factors in the epidemiology of leukemia in Hiroshima and Nagasaki.
In 303 pairs of patients and controls the risk of leukemia with onset during 1945 to 1967 in Hiroshima or Nagasaki was 2.5 times higher among those with a history of probable occupational exposure to benzene and medical x rays. Expand
Haematological effects of chronic benzene poisoning in 217 workers
It is concluded that benzene exerts its harmful effect, primarily on the leucocytes, with eosinophilia and basophilia as inconstant findings, secondarily on the platelets causing thrombocytopenia, and finally on all three series giving rise to pancytopania. Expand
Skin cancer in chronic arsenicism.
  • S. Yeh
  • Medicine
  • Human pathology
  • 1973
Abstract In a limited area on the southwest coast of Taiwan where artesian well water with a high concentration of arsenic has been used for more than 50 years, a high prevalence of chronicExpand
Formation of K-region epoxides as microsomal metabolites of pyrene and benzo(a)pyrene.
Epoxides of pyrene and benzo[a]pyrene have been detected for the first time as microsomal metabolites of these polycyclic hydrocarbons in relation to the hypothesis that polycyclie hydrocarbon carcinogenesis results from somatic mutations caused by epoxides that are formed from the Hydrocarbons by metabolism. Expand
Benzene and leukemia.