Long-term efavirenz use is associated with worse neurocognitive functioning in HIV-infected patients

@article{Ma2015LongtermEU,
  title={Long-term efavirenz use is associated with worse neurocognitive functioning in HIV-infected patients},
  author={Qing Ma and Florin Vaida and Jenna Wong and Chelsea A Sanders and Yu-ting Kao and David J. Croteau and David B. Clifford and Ann C Collier and Benjamin B. Gelman and Christina M. Marra and Justin C. Mcarthur and Susan Morgello and David M. Simpson and Robert K. Heaton and Igor Grant and Scott L Letendre},
  journal={Journal of NeuroVirology},
  year={2015},
  volume={22},
  pages={170-178}
}
Neurocognitive (NC) complications continue to afflict a substantial proportion of HIV-infected people taking effective antiretroviral therapy (ART). One contributing mechanism for this is antiretroviral neurotoxicity. Efavirenz (EFV) is associated with short-term central nervous system (CNS) toxicity, but less is known about its long-term effects. Our objective was to compare NC functioning with long-term use of EFV to that of a comparator, lopinavir-ritonavir (LPV/r), in a cohort of well… CONTINUE READING
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Manual for the beck depression inventory-II

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