Long-term down-regulation of BDNF mRNA in rat hippocampal CA1 subregion correlates with PTSD-like behavioural stress response.

@article{Kozlovsky2007LongtermDO,
  title={Long-term down-regulation of BDNF mRNA in rat hippocampal CA1 subregion correlates with PTSD-like behavioural stress response.},
  author={Nitsan Kozlovsky and Michael Alex Matar and Z. Furkan Kaplan and Moshe Kotler and Joseph Zohar and Hagit Cohen},
  journal={The international journal of neuropsychopharmacology},
  year={2007},
  volume={10 6},
  pages={741-58}
}
Brain-derived neurotrophic factor (BDNF) and its intracellular kinase-activating receptor TrkB, have been implicated in the neurobiological mechanisms underlying the clinical manifestations of PTSD, especially those related to synaptic efficacy and neural plasticity. BDNF interacts with components of the stress response such as corticosterone, and plays an… CONTINUE READING